Founded in 1969, Biotrading Srl was established as a company operating in the pharmaceutic l and nutritional sectors. Originally, the pharmaceutical production facilities were located at the registered office in Milan, while the nutritional division's production was based in Florence.

In 1987, the company initiated a major corporate reorganisation, separating the pharmaceutical and nutritional divisions. The pharmaceutical sector retained its headquarters and production activities in Milan, while the food division was relocated to Marsala, with a production facility in Florence, adopting advanced food production technologies and methodologies derived from pharmaceutical expertise applied to food supplements from the outset.

From 1999 onwards, Biotrading embarked on a path of strong specialisation in infant nutrition, focusing its activities on the neonatal and paediatric fields. The company became a reference point in Italy for the production of food supplements dedicated to premature infants, developing scientifically grounded products such as Proton and Folium, and patenting innovative vitamin and nutrient delivery systems.

From 2006, Biotrading consolidated its scientific positioning by participating in the leading national medical-scientific congresses and promoting symposia, round tables, and specialist meetings dedicated to nutrition and health topics. At the same time, it strengthened its editorial presence through communication activities in the main scientific reference journals.

In 2009, the company launched an internationalisation process, bringing its products to foreign markets, where it gained growing recognition for quality, reliability, and innovation.

In 2011, Biotrading entered into a collaboration with the Department of Food Science at the University of Messina, aimed at developing new production techniques and continuously monitoring the quality of the company's processes.

2016 marked a year of significant strategic expansion: the company strengthened its digital presence through online communication tools, social media, e-commerce, and scientific information channels; it opened two single-brand retail stores in Marsala; and it launched a new product line dedicated to the gynaecological and obstetric fields, accompanied by the creation of a specialised medical-scientific information network.

From 2017, Biotrading has participated as an exhibitor at CPHI Worldwide, one of the most important international events dedicated to the pharmaceutical industry. Its continued presence at the event has contributed significantly to the company's international expansion, reinforcing the promotion of Made in Italy values in global markets.

In 2023, Biotrading began a new journey oriented towards environmental sustainability, relocating part of its production to facilities in Catania. The plants are powered by solar panels, and the company has adopted biodegradable and recyclable packaging solutions made from FSC-certified paper. At the same time, the regulatory team continues to operate in ongoing dialogue with regulatory bodies, specialist consultants, and industry associations.

From 2023, Biotrading has participated as an exhibitor at Arab Health Dubai, the leading international event for the medical and healthcare sector in the Middle East & North Africa region, reaffirming its commitment to international development and the promotion of Italian excellence in the healthcare sector.

In 2026, Biotrading became a partner of the Second-Level Master's Programme in Economics and Management of Pharmaceutical and Biotech Companies promoted by the University of Palermo, further strengthening its ties with the academic world and advanced professional training.

Biotrading participated as an exhibitor at World Health Expo (WHX) Dubai, the new name of the historic Arab Health trade fair, held at the Dubai Exhibition Centre – Expo City (Dubai). The event welcomed 68,000 visitors from 193 countries and over 4,000 exhibitors.